Overall statistical heterogeneity for plasma cysteine was considerable (I 2 = 92%) and low to moderate between diagnostic subgroups (I 2 = 39.8%)
In PCOS, ovarian tissues and GC is characterized by diminished expression of biogenesis regulatorsPGC-1, nuclear respiratory factor 1 (NRF-1) and mitochondrial transcription factor A (TFAM) alongside increased mitochondrial DNA (mtDNA) damage and fragmentation, and ultrastructural abnormalities such as disorganized cristae, swelling, and vacuolization ( 6.3 Alleviating transzonal projection damage Transzonal projection (TZP), specialized cytoplasmic extensions connecting granulosa cells with the oocyte, emerge as critical mediators of bidirectional communication during early folliculogenesis, becoming detectable coincident with zona pellucida formation
Minelli C, Granell R, Newson R, Rose-Zerilli MJ, Torrent M, Ring SM, et al
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