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Semaglutide was developed based on GLP-1(7-37) backbone, its Lys side chain was modified with a long chain fatty acid, enabling it to bind to plasma albumin for slower drug release

Meanwhile, long-chain saturated fatty acids, represented by palmitic acid, have an inhibitory effect on circadian rhythms

That said, several indirect mechanisms could potentially contribute to breathing difficulties in patients taking Ozempic: The medication's effect on gastric emptying and its association with gastrointestinal side effects may lead to bloating, abdominal distension, or gastro-oesophageal reflux, which can occasionally create a sensation of breathlessness or chest tightness