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Description

Altogether, NRF2 is a transcriptional factor of GCLC, and ACTL6A co-works with NRF2 and affects NRF2 binding to the promoter of GCLC, thereby regulates GCLC expression at the transcriptional level

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Initial Assessment: Before starting treatment, a patient's cardiovascular status

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In hemoglobinoathies (mainly SCD and thalassemias, but not limited to), the hemoglobin S and globin dimers are prone to lose heme through the formation of unstable hemichromes [237]

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