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Original isolation of dermorphin from frog skin and determination of the sequence H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2, notable as a vertebrate peptide containing a D-amino acid residue

4.2 Direct evidence Regarding direct mechanisms, urolithin A may have potential modulatory effects on central clock genes ( Clock , Bmal1 , Per , Cry ), a pathway partially supported by existing preclinical data