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Cryo-EM analysis of a complex involving an Ex4 analog, the GLP-1R and G s heterotrimer revealed two receptor conformers with distinct modes of peptidereceptor engagement

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This is particularly due to its capacity to regulate appetite and food intake, making it a compelling option for individuals striving to manage their weight through medical means

Generally, if the receptors are ligand-gated ion channels, a conformational change opens the ion channels, which leads to a flow of ions across the cell membrane resulting in either a depolarization, for an excitatory receptor response, or a hyperpolarization, for an inhibitory response [277]