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There are also certain drugs and health conditions that can increase the likelihood of developing a B12 deficiency, such as: alcohol abuse, antacid use, smoking, celiac disease, other digestive concerns, pregnancy, a strict vegetarian or vegan diet, and even natural aging

Lentz SR and Sadler JE (1993)

Endothelin receptor antagonists (ERAs) have been studied in diabetes and CKD for over a decade, with early studies ending prematurely because of complications associated with fluid retention

Zustzlich spricht aus Sicht der Leitlinie fr den Einsatz, dass ein vergleichbarer oder grerer Therapieeffekt bei insgesamt akzeptablem Risikoprofil zu erwarten ist