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Maheswari UK, Vijayalakshmi B, Kumar MV, Jaleena EK, Anandan H

Even in people who dont have migraine, dehydration can lead to headaches, and in people who do, it can lead to migraine attacks

Systemic administration (injectable or oral), which is less common than topical use and not part of approved or standard applications, would theoretically carry different safety considerations requiring appropriate clinical evaluation, though limited research on parenteral administration in animals has suggested acceptable safety profiles at moderate doses

GDF15 provides an endocrine signal of nutritional stress in mice and humans