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Part of developing a good growth strategy involves identifying how much innovation is appropriate at a given time
The more open TMD in the static exendin-4 bound cryo-EM structure was associated with fewer stable peptide contacts (Supplementary Table 1), relative to GLP-1 and oxyntomodulin, however, the cryo-EM map was a lower resolution, which precluded modelling of some of the binding site (top of TM6, ECL3 and ECL1)
Although GLP-1 drugs are often used as long-term maintenance therapy because stopping them commonly leads to weight regain, there is still limited data on their effects over a full lifespan in older adults, especially frail older adults
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