International Journal of Molecular Sciences, 21 (15), 5342
Allen M, Huang B, Notaras M, Lodhi A, Barrio-Alonso E, Lituma PJ, Wolujewicz P, Witztum J, Longo F, Chen M, Greening DW, Klann E, Ross ME, Liston C, Colak D (2022) Astrocytes derived from ASD individuals alter behavior and destabilize neuronal activity through aberrant Ca2+ signaling
The first evidence that eNOS uncoupling may be a pathophysiologically relevant phenomenon was provided by in vitro studies in which it was demonstrated that native low-density lipoprotein 81 and even more pronounced oxidized low-density lipoprotein 82 are able to stimulate endothelial superoxide production and that this phenomenon is inhibited by the NOS inhibitor N G -nitro-L-arginine methyl ester, pointing to a causal role for eNOS in superoxide production
Each month, during a womans menstrual cycle, a follicle (a small sac in the ovary) grows and releases an egg