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Everything below is a proposed mechanism with varying and generally weak support
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The half-life of tirzepatide is about 5 days, which means steady state arrives around week 3 to 4 at each dose
Use of the peptide Ac-Nle-cyc/o(-Asp-His-D-Phe-Arg-Trp-Lys)-OH for the manufacture of a medicament for use in the treatment by multiple agent therapy with a PDE-5 inhibitor for the treatment sexual dysfunction, wherein the amount of each of the peptide Ac-Nle- cyc/o(-Asp-His-D-Phe-Arg-Trp-Lys)-OH and the PDE-5 inhibitor is not sufficient, if administered as monotherapy, to independently initiate the desired pharmacological response in the patient
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