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[13] One Dutch study found that after adjustment for gender and age, there was a statistically significant negative association between the use of metformin and vitamin D status, with those who did not use a vitamin D supplement having levels of vitamin D 14.4 percent lower than controls

In addition, exposure of HepG2 (human hepatoblastoma cell line) to H 2 O 2 has been demonstrated that would increase ROS levels and induce ER stress in a dosage-dependent manner (34)

Menopause 21(6):p 602-611 DOI: 10.1097/GME.0000000000000192 Greendale, GA, Huang MH, Wight RG, Seeman T, Luetters C, Avis NE, Johnston J, Karlamangla AS

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