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Results of previous studies on topical gel formulation of hydroquinone-loaded SLNs indicated a significantly higher drug deposition within the epidermis layer (46.5% 2.6%) in comparison to the conventional gel of hydroquinone (15.1% 1.8%) ( in vitro permeation study on rat skin revealed that drug accumulation within the skin layers was approximately 3 times higher, while the drug flux into the receptor phase of Franz cells was about 6.5 times lower in hydroquinone-loaded SLNs in comparison to the hydroquinone gels which confirmed the reduced systemic absorption and further reduced adverse drug reactions through the encapsulation in SLNs (Wu et al., 2017)

The growth hormone elevation from secretagogues amplifies the muscle-building response to resistance training