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In lactating cows, hindgut microbial-mediated secondary BAs metabolism was closely associated with plasma glucose and BHBA levels, mainly through remodeling taurine-conjugated and deconjugated BAs profiles to influence lipid absorption, suggesting the hindgut microbiotaBAs axis is critical for adapting to periparturient negative energy balance 85

Future research with a larger number of patients, can provide new insights regarding the molecular mechanisms as well as modifiable factors to decrease OS in this clinical entity

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our skin starts to produce less cholesterol with age