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It offers an alternative for those averse to injections but has different absorption rates and pharmacokinetic properties that may affect its efficacy and side effect profile
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Semaglutide 2.4 mg (Wegovy) has shown robust weight loss in primary obesity trials, with mean weight reductions of 14.9% in the STEP 1 trial published in the New England Journal of Medicine (2021)
Overall, the primary composite endpoint occurred in 331 patients of 1767 (18.7%) on Ozempic (1 mg) and 410 patients of 1766 (23.2%) on placebo (HR, 0.76 [95% CI: 0.66-0.88] P =0.0001 for superiority)
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