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Andrea Tenner, a neurobiologist at the University of California, Irvine, says that inhibiting certain microglial complement receptors has shown promise in mouse models of Alzheimers and is being tested in other human neurodegenerative diseases

Conditions such as systemic lupus erythematosus (SLE) are not included, despite their potential to cause pre-senile dementia through mechanisms like autoimmune antibodies targeting sodium channels on glutamatergic neurons [495]

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For example, in-depth mining of the TCMBank database has uncovered numerous bioactive compounds and their associated targets linked to depression, enabling the construction of comprehensive componenttargetdisease network models