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How They Work: Breaking Down the Mechanisms Understanding why these compounds produce different results requires examining their receptor interactions at a molecular level

doi: 10.1002/ejhf.1596 65 SolomonSDMcMurrayJJVClaggettBde BoerRADeMetsDHernandezAFet al

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4.1.2 RCTs Several blinded, placebo-controlled RCTs have demonstrated a significant reduction in HbA1c when adding GLP-1RA to either multiple daily injections (MDI) or continuous subcutaneous infusion of insulin (CSII), ranging between 0.1-0.7% (5261) ( Table 1 )