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TT-OAD2 is another small molecule that also exhibits biased agonism in a unique binding mode [46]

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Recommended first-line choices in the guideline from the Canadian Network for Mood and Anxiety Treatments (CANMAT) and the International Society for Bipolar Disorders (ISBD), The most recent authoritative international guideline for the management of patients with bipolar disorder by the CANMAT and the ISBD (2018) [12] recommends the following first-line drugs for bipolar depression: quetiapine, lithium, lamotrigine and lurasidone