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This is likely due to greater weight loss seen in this trial, approximately 21% with 15 mg dosing, far exceeding the 14% weight loss observed in GLP-1 RA trials [14, 16, 19, 20, 23]

The practical tips for semaglutide protocols guide covers a range of strategies for reducing day-to-day discomfort that apply here

Poor sleep increases ghrelin (hunger hormone) and decreases leptin (satiety hormone), making weight loss more difficult

The American Academy of Ophthalmology has not recommended that patients stop using semaglutide, but rather, that patients experiencing vision loss while taking semaglutide should stop the drug and contact the physician prescribing the medication