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Mesenchymal stem cell studies demonstrate dose-dependent VEGF and bFGF increases mediated through integrin 1 and 1 pathways with no cytotoxic effects across wide concentration ranges
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Interestingly, the same pathway may also be utilized during inflammatory responses, mediated by the tumor necrosis factor-alpha (TNF-)
More recently, such workflows have been utilized to build target-specific, natively paired immune libraries and demonstrate the greater likelihood of natively-paired binders to specifically and sensitively bind their target relative to counterparts with non-native chain pairings 16,19
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