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Patients with high-sensitivity variants often achieve target weight loss at lower doses, reducing cost and side effects

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It was posited that neither clinical examination nor diagnostic imaging showed a significant accumulation of fluid in the tissues of patients with lipedema, and therefore, the term lipedema was labeled as outdated and suggested that it could be renamed as lipalgia syndrome.24 Metabolic and cardiovascular changes Although lipedema is frequently associated with a high Body Mass Index (BMI), accumulating evidence suggests that its metabolic profile may differ from that typically seen in generalized obesity