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[51] Substitutions are made at GLP positions 8 and 34 (semaglutide positions 2 and 28), where alanine and lysine are replaced by 2-aminoisobutyric acid and arginine, respectively

Among the transgenic cohorts, those treated with intranasal GHKCu had significantly fewer detectable plaques or protein aggregates in comparison to those receiving intranasal saline