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GLP-1 medications such as semaglutide work by influencing appetite signaling and slowing gastric emptying

Increased Glucagon Release: Unlike GLP-1, GIP increases the release of glucagon in a glucose-dependent manner

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GIP receptor activation works synergistically with GLP-1 enhancing insulin release, improving adipose tissue metabolism, improving lipid handling, and critically, moderating the gastrointestinal side effects that limit tolerability of pure GLP-1 agonists