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GPX4 plays a key role in preventing ferroptosis, a type of cell death characterized by iron-dependent accumulation of lipid ROS

Specifically, BPC 157 inhibited the mRNA of inflammatory mediators (iNOS, IL-6, IFN, and TNF-), increased the expression of HSP 70 and 90, and antioxidant proteins (such as HO-1, NQO-1, glutathione reductase, glutathione peroxidase 2, and GST-pi) ( Further, we should appreciate the noted methodology point (i.e., the vascular failure obtained by retrobulbar L-NAME injection and by therapy counteracted, as specific major findings, and the normal intraocular pressurethe severe eye damage)