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Medications with a Narrow Therapeutic Index Some medications are considered to have a narrow therapeutic index. This means the difference between a dose that works and a dose that is toxic is very small
Furthermore, a network meta-analysis examining the effects of GLP-1 RA therapy on body composition reported a greater reduction in lean body mass in the intervention group compared with placebo or active comparators (mean difference = 0.86 kg, 95%CI: 1.30, 0.42)
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Both agents demonstrated favorable effects on liver enzyme levels and lipid profiles
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