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852 A significantly reduced Zn II affinity of the Mg II GDP-bound OFF state may well provide a (shallow) thermodynamic driving force for metalation of a client protein (Figure 48A), exactly in line with thermodynamic gradients previously observed in sequential Cu I trafficking reactions, 806 and analogous to proteinprotein interaction affinity gradients recently observed in [4Fe-4S] cluster enzyme maturation

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BPC 157, or Body Protective Compound 157, is a peptide therapy derived from a naturally occurring protein in the human body