This process involves: Combining Secondary and Primary Research By integrating both secondary and primary research methodologies, we ensure that our database is comprehensive, accurate, and up-to-date

4 Discussion Current evidence strongly supports the efficacy of GLP-1 receptor agonists for inducing substantial weight loss, improving metabolic control, and reducing cardiovascular risk often surpassing the short-term effects of exercise alone ( Exercise and lifestyle interventions, while generally less potent for weight loss, provide unique and irreplaceable health benefits preserving skeletal muscle, improving cardiorespiratory fitness, enhancing psychological well-being, and lowering chronic disease risk ( Hybrid care models that integrate pharmacotherapy with behavioral support are emerging as the most promising framework for sustainable obesity and diabetes management ( Persistent challenges include the high cost and limited accessibility of GLP-1RAs, variable long-term adherence, and a lack of long-term data on sustainability, relapse rates, and overall health outcomes

The positive correlation between GST gene polymorphisms and hepatocellular carcinoma caused by hepatitis B virus chronic infection [55] and uterine cancer associated to human papilloma virus infection was described [56] (Figure 3)
GLP-1 and Progesterone By regulating insulin and reducing fat storage, GLP-1 supports progesterone balance and hormone stability