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The substantial weight loss achieved with GLP-1 receptor agonists and dual GIP/GLP-1 agonistsapproximately 15% with semaglutide 2.4 mg (Wegovy) and up to 21% with higher doses of tirzepatide (Zepbound) in clinical trialsoccurs primarily through appetite suppression and reduced caloric intake rather than increased metabolic rate

The Critical Lean Mass Question The most reassuring finding for body recomposition purposes concerns lean mass preservation

[2] [3] Important considerations when restarting: Dose considerations : If you have missed several doses or been off semaglutide for an extended period, discuss with your prescribing physician whether to restart at your previous dose or re-titrate from a lower dose according to product labeling