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The good news is that most sleep-related issues resolve as treatment continues, and many patients ultimately sleep better due to reduced sleep apnea and nighttime reflux as weight decreases

The FDA approved oral semaglutide (the Wegovy pill) for weight management in December 2025, giving patients a daily tablet option alongside the traditional once-weekly injection

For tirzepatide, patients should be advised that oral contraceptive effectiveness may be reduced during initiation and dose escalation