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In the ITT population, after a median follow-up of 6.2 months, patients who received cabozantinib showed significant improvement in PFS compared with patients who received placebo (median not reached [96% CI, 5.7not estimable (NE)] vs

Switch to 500 mcg every other morning (EOD) as soon as Phase 1 effects are observed The every-other-day schedule reduces cumulative exposure while maintaining metabolic benefits Monitor how your body responds: appetite suppression should persist between doses at this frequency The shift from daily to EOD is not optional once effects are felt

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Betaine supplementation attenuates atherosclerotic lesion in apolipoprotein E-deficient mice