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Patients who develop symptoms of unexplained hyperammonemic encephalopathy while receiving valproate therapy should receive prompt treatment (including discontinuation of valproate therapy) and be evaluated for underlying urea cycle disorders [seeContraindications (4)andWarnings and Precautions (5.10)]

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This leads to an increase in the expression of caspase 3 , ICAM, TNF- , or IL-6 genes

Quality inspection: The purified polypeptides need to undergo mass spectrometry analysis, amino acid sequence determination and purity testing to ensure they meet the quality requirements