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Subcutaneous injection offers bioavailability of approximately 15-20% based on animal data, while intramuscular administration may provide 45-50% bioavailability in some species

bottom quartile, hazard ration (HR), 0.79

But this protection is not automatic

He stated, Semaglutide 2.4 mg not only reduces the first event risk but also lowers the cumulative cardiovascular burden making it a foundational therapy for secondary prevention in obesity-related cardiovascular disease Vince Lamanna, President of Novo Nordisk Canada, commented that these results expand the meaning of cardiovascular care by integrating obesity treatment as a proven strategy to prevent future events. He highlighted that Health Canadas decision to approve semaglutide 2.4 mg for patients with established CVD and overweight or obesity was the first global regulatory recognition of obesity therapy as a cardiovascular indication