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Comparing GLP-1 Weight Loss Medications Potential Side Effects of GLP-1 Medications Common side effects include: Nausea, bloating, or diarrhoea Fatigue or headaches Constipation during dose escalation Rarely: pancreatitis or gallbladder inflammation Most symptoms improve over time

While lixisenatide was found to be the only GLP-1RA subtype to increase the risk of MI, it is important to consider that the ELIXA trial, which studied lixisenatide in patients with T2DM, had the highest risk population as it included participants with recent acute coronary events in the past 180 days [40]

Discomfort is minimal, and any soreness at the injection site typically resolves within a few hours

Enhanced Safety and Efficacy : By accessing WEGOVY or ZEPBOUND through Evernorth's pharmacy benefit, patients will benefit from FDA-approved medications and Express Scripts' robust safety checks designed to reduce negative or adverse drug interactions