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Finally, the acute administration of high doses of MPH can cause oxidative and inflammatory changes in brain cells and induce neurodegeneration in the hippocampus and cerebral cortex of adult rats [137]

Jens Juul Holst also isolated and identified GLP-1 (1-37), and subsequently GLP-1 (7-36) amide as an active incretin

Previous studies have observed that GLP- 1R expression was detected by autoradiography in normal tissues such as islets of the pancreas and Brunners glands of the duodenum [20, 22]

Arch Neurol 39(8):46174 Yri HM et al (2012) Idiopathic intracranial hypertension is not benign: a long-term outcome study