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Pharmacological, non-pharmacological and surgical interventions have been implemented in order to put an end to obesity and its complications, however, most of these therapies have failed because there is no sustained weight loss over time, so the use of GLP-1 receptor agonists has been implemented as effective drugs for weight reduction and modification of cardiovascular risk factors

Dietary supplementation with 1% and 2% glycine to Phase-I HSB increased guanidinoacetate concentrations in skeletal muscle in a dose-dependent manner (Table 1)

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