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Analyzing the FDA Adverse Event Reporting System showed sitagliptin to be the drug reported to cause the most hypoglycemia, whereas the hypoglycemic potential of the meglitinides (short-acting sulfonylurea analogs) was not picked up as significant and the hypoglycemic potential of sulfonylureas and even of insulin was greatly underestimated when these results are compared with well-known epidemiological data (Supplementary Fig

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