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10.1093/alcalc/agaf069 104 PazienzaV.ClementS.PugnaleP.ConzelmanS.FotiM.MangiaA.et al (2007)

First, although it was a prospective multicenter trial, it was still a single-arm study without a placebo

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The evidence that does exist belongs to the parent compounds and must be tiered honestly: Semax: registered in Russia (a national approval, not FDA/EMA) for ischemic stroke and related indications, supported mainly by Russian clinical studies that are frequently non-randomized, open-label, or small, plus a substantial preclinical literature