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It is most critical for patients over 50, perimenopausal or postmenopausal women, and anyone with prior sarcopenia or low baseline muscle mass

Maximum approved doses are 15 mg weekly for both diabetes management and weight management

Given that GLP-1-RAs alter gut motility and secretion, and that the gut microbiota can influence host eating behavior, including food preferences, it is plausible that these drugs indirectly influence taste perception by modulating microbial composition and the subsequent production of metabolites that can signal to the brain, potentially via vagal afferents or systemic circulation

References FDA