Olfaction has been recognised as having significant impact on the control of energy balance 16,34 and olfactory disorders have been shown to influence eating behaviour and whole-body metabolism 11
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This condition is associated with a range of systemic complications, including cardiovascular, pulmonary, and psychological disorders ( Figure 2 ) ( Figure 2 RA is classified into two major subtypes based on the presence or absence of anti-citrullinated protein antibodies (ACPAs), detectable in around 67% of patients and serving as a key diagnostic marker ( Porphyromonas , Epstein-Barr virus, and gingivitis, along with noxious agents, dietary factors, and the gut microbiome, also contribute to ACPA generation (50)