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Focal adhesion A large, dynamic protein complex in which the cytoskeleton of a cell connects to the ECM through integrins

Subsequent oxidative stress results in the age-dependent peroxidation of proteins, lipids, and nucleic acids by intracellular mitochondria, destruction of the mitochondrial membrane permeability, and reduction of oxygen respiratory chain activity, leading to an increase in the number of active oxygen species (Gotoh et al., 2012

Elevations in blood pressure (180 mmHg systolic or 110 mmHg diastolic) were observed in approximately 18% of healthy subjects (not exposed to cyanide) receiving hydroxocobalamin 5 g and 28% of subjects receiving 10 g

Sources: Benoist CC, et al