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The pharmacokinetics of the active agent are already considerably different between humans and rodents

The metabolites produced by arachidonic acid (AA) via the LOX and COX pathways can induce the production of ROS by activating NOX [14, 15]

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323,324 Astrocytes differentiated from pluripotent stem cells isolated from Duchenne muscular dystrophy patients (and carrying mutant DMD gene) were characterised by abnormal cytoskeleton, severely deficient glutamate uptake, and compromised K + buffering