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It also oxidizes thiol groups of proteins, forming disulfide bonds that alter Bcl-2 family protein conformation and function, disrupting the balance between pro-apoptotic and anti-apoptotic proteins [79]

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The intrinsic, or mitochondrial, pathway is activated by honeys polyphenolic components that cause mitochondrial membrane depolarization and activate caspases 3, 7, and 9 (84, 85)