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Fang P, Kazmi S, Jameson K, Hsiao E

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Research from the STEP 1 exploratory analysis using DEXA scans revealed that semaglutide-induced weight loss comprises approximately 60 percent fat mass and 40 percent lean mass

Still, this evidence was not confirmed in the CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) trial, which evaluated canagliflozin in patients with DM and chronic kidney disease, and was further averted by a pooled analysis of CANVAS and CREDENCE, which showed no increased risk of MALE with canagliflozin and its greater benefits in patients with PAD