Results from the SURMOUNT-1 trial showed that treatment with tirzepatide (10 or 15 mg) was associated with greater improvements in the SF-36v2 physical functioning scores from baseline to week 72, compared with placebo, among participants with obesity without T2D [11, 33]
Complicated diseases are often treated by attacking multiple biologic mechanisms at once, so why should obesity be any different
In some animal experiments, it has been reported that GLP-1 may be effective in improving inflammation [27,28], postprandial hyperlipidemia [29,30], endothelial cell dysfunction [31], and oxidative stress [32], as well as protecting -cells [33,34]
This makes Wegovy a closer competitor to Mounjaro in terms of intended use