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While postbiotics are unlikely to replicate the magnitude of weight loss achieved with GLP-1RAs, their continuous, physiology-aligned mode of action positions them as biologically plausible adjuncts that may support weight-loss sustainability and improve the metabolic context for lean mass preservation

[] GLP-1RA is increasingly recognized as a potential neuroprotective agent because of its anti-inflammatory properties, making it a promising therapeutic option for neurodegenerative conditions

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The newly published - in Nature Medicine showed that patients switching from injectable GLP-1 therapies to once-daily oral Orforglipron were able to maintain most of their achieved weight loss over 52 weeks