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Opioid-Related Pathways Animal work suggests that some DSIP effects may involve endogenous opioid signalling

The monoamine hypothesis of depression has been the main pathophysiology and drug therapy target of depression over the past few decades, but the current monoamine theory has serious limitations (105)

Semaglutide is also included in the next round of Medicare drug price negotiations under the Inflation Reduction Act, which Biden signed into law in 2022

Therapy should be evaluated and lab work should be reviewed to see what the levels are, determine if the levels are low, determine if the levels are rising appropriately with therapy, and assure that this therapy is having an effect and is needed and useful