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The landmark STEP 1 trial, published in the New England Journal of Medicine , involved nearly 2,000 adults with obesity but without diabetes

The most frequently reported side effects are mild digestive symptoms such as nausea, stomach discomfort, diarrhea, or cramping

Those drugs mimic this hormone in a more sustained way than your body can on its own, since natural GLP-1 only sticks around in your bloodstream for a couple of minutes

We present this article in accordance with the Narrative Review reporting checklist (available at Methods A search of the literature was conducted on OVID (1947May 2025) using the terms [papilledema OR intracranial hypertension OR idiopathic intracranial hypertension OR brain pseudotumor] AND [glucagon like peptide 1 OR glucagon like peptide 1 receptor agonist OR semaglutide OR exendin 4 OR liraglutide OR tirzepatide]