[DOI] [PubMed] [Google Scholar] 64.Davis A.K., Barrett F.S., May D.G., Cosimano M.P., Sepeda N.D., Johnson M.W., Finan P.H., Griffiths R.R
This phenomenon may be attributed to the fact that once a chronic inflammatory milieu is established, iron becomes sequestered within the macrophages of the reticuloendothelial system and the brains microglia, rendering it inaccessible to chelation
What to supplement: Start with low doses of methylated B vitamins (e.g., 400-800mcg methylfolate, 500-1000mcg methyl-B12) Increase gradually while monitoring symptoms Include B6 and other B-complex vitamins Retest homocysteine after 2-3 months If low homocysteine is accompanied by low SAMe: If testing shows both low homocysteine and low SAMe, you may benefit from methylation support
Detection windows from studies represent averages