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This is analogous to the evidence pathway followed for liraglutide (LEADER trial, NEJM 2016) and semaglutide (SUSTAIN-6 trial, NEJM 2016), which established cardiovascular benefit for those agents only after large, long-term CVOTs reported [6] The heart rate increase warrants ongoing surveillance, particularly in patients with pre-existing cardiac conditions Phase 3 trials are currently underway (see ClinicalTrials.gov and the EU Clinical Trials Information System, CTIS, for registered studies)