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4.1 Pharmacokinetic and pharmacodynamic considerations of antioxidant supplementation in AMS As mentioned above, oxidative stress has been proposed as a key contributor to the pathophysiology of AMS, driven by hypobaric hypoxiainduced mitochondrial dysfunction, increased ROS generation, endothelial activation, and neurovascular dysregulation

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The chemical name of levocarnitine is 3-carboxy-2( R)-hydroxy-N,N,N-trimethyl-1-propanaminium, inner salt