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Mechanism of Action of GLP-1-R Agonists GLP-1-R agonists function by activating the GLP-1-R receptor in multiple organs

Co-treatment of 4d (A2-thio-imidazole derivative), a novel TGR5 agonist, and Sitagliptin (DPP-4 inhibitor) exhibited a GLP-1 secretion and glucose-lowering effect in animal models, while this compound alone exhibits only a slight 1.3-fold increase in GLP-1 secretion [182]

GLP-3s effects on insulin secretion are under investigation, with early research suggesting it may influence insulin sensitivity through somewhat different pathways